MO672HIGH FLUX VERSUS LOW FLUX HEMODIALYSIS: A PRE-POST STUDY

Abstract Background and Aims High flux hemodialysis has largely replaced low in developed countries. Clinical trials, particular the Hemo MPO studies, conducted many years ago, showed that survival benefit was mainly for patients on long term first one high risk with albumin level (less than 40g/dl) latter. Moreover, effect hematopoiesis or mineral balance is not unequivocally established literature. In Lebanon, following recommendations of ministry health, we switched undergoing at our center from to starting April 2019. We aimed this study assess switch hemoglobin level, dose ESA used, metabolism parameters nutritional parameters. Method This an observational pre-post where each patient his own control. Subjects included are adults chronic more 6 months Hotel Dieu de France University Hospital. Patients who needed transfusion bleeding, admission hospital parathyroidectomy during period were excluded study. Demographic parameters, medical history laboratory values extracted patients’ files. Paired t- test used compare obtained compared hemodialysis. Results Seventy four received sequentially both techniques (45 males 29 females). Mean age 66 years, mean dialysis vintage 65 months, diabetic vascular diseases most frequent causes ESRD found 27 15% cases. Hemoglobin significantly increased 11 +/- 0.82 11.26 0.67 mg/dl (p=0.04) a non-significant trend towards lower dose: 11620 UI/week (+/-2275 UI) versus 10860 (+/-2609 second (p=0.15). Ferritin levels higher part (416 v/s 476 ng/ml) which may have contributed increase hemoglobin. Phosphorus decreased 1.55 1.48 mmol/l (p=0.008) same doses binders practically stable calcium PTH. Most interestingly, 38 40.3 g/dl (p<0.001). Finally urea reduction ratio 73.1% 74.5% p value 0.001. Conclusion Assuring quality ultrapure water still challenge developing Lack firm evidence beneficial terms mortality delay sanitary authorities imposing study, switching positive impact phosphorus but interestingly major predictor patients.